Clinical Relevance for the RH Blood Group System

Program Date: 3 August 2023
Publication Date: 27 September 2023
Continuing Education Units: 1.0 hours

Lecture Description:

In this lecture, Dr Denomme provides a review of the RH system and D antigen variants. He then discusses RhD discrepancy studies and then provide RHD genotyping recommendations.

Lecture Objectives:

• Review the RH system: gene organization, biochemistry, and antigens 
• Understand the classification of D antigen variants 
• Identify one reason why specific D epitopes are targeted by anti-D antisera 
• Summarize new recommendations for RHD genotyping
  • Run Time: 32 minutes

Lecture Instructor Bio(s)

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Gregory Denomme, PHD, FCSMLS(D)

Laboratory Director and Head of Research and Development 
Grifols Laboratory Solutions 
Sanarcos, TX, USA
Dr Denomme is a clinical and academic trained scientist. He obtained a doctorate in microbiology and immunology and completed postdoctoral fellowships in platelet immunology and in Pathology and Molecular Medicine. Past academic appointments in include Associate Professorship, Laboratory Medicine and Pathobiology at the University of Toronto, and Senior Investigator with Versiti’s Blood Research Institute in Milwaukee. Presently, Dr Denomme is the Laboratory Director and Head of Research and Development at Grifols Laboratory Solutions in San Marcos, Texas. His applied research integrates blood group genetics and immunohematology to the study of blood group antigen expression and its impact on immune-mediated hemolytic disorders.

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